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Click here to see all Cullen Lab publications.

Key publications are listed below:

Butkovič R, Healy MD, de Heus C, Walker AP ... Cullen PJ. Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7. Nat Commun. 2025 Oct

Antón-Plágaro C ... Cullen PJ. Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation. Nat Commun. 2025 Jul

Kato K ... Cullen PJ. Ritscher-Schinzel syndrome can be characterized as an endosomal recyclinopathy. Sci Transl Med. 2025 Jul 2

Daly JL, Chen KE, Butkovič R ... Cullen PJ. Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition. Proc Natl Acad Sci U S A. 2025 Jul

Butkovič R ... Cullen PJ. Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway. Nat Commun. 2024 Aug

Guo Q, Chen KE, Giménez-Andrés M ... Cullen PJ, Collins BM. Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. PNAS. 2024 Aug

Daly JL, Danson CM, ... Cullen PJ. Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health. Nat Commun. 2023 May

Healy MD, McNally KE, Butkovič R, Chilton M, ... Cullen PJ. Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell. 2023 May

Simonetti B, Daly JL, ... Cullen PJ. ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1. Proc Natl Acad Sci U S A. 2022 Jun

Simonetti B, Guo Q, Giménez-Andrés M, ... Cullen PJ. SNX27-Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling. PLoS Biol. 2022 Apr

McMillan KJ, Banks PJ, ... Cullen PJ. Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2. Elife. 2021 Jul

Daly JL, Simonetti B, Klein K, ... Cullen PJ, Yamauchi Y. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 2020 Nov

Curnock R, Cullen PJ. Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1. J Cell Sci. 2020 Aug

Evans AJ, ... Cullen PJ. Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting. J Cell Sci. 2020 Aug